Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation
نویسندگان
چکیده
منابع مشابه
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
The decline in hematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of hematopoietic stem cells (HSCs). The molecular mechanisms underlying HSC aging remain unclear. Here we demonstrate that elevated activity of the small RhoGTPase Cdc42 in aged HSCs is causally linked to H...
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Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during aging, the stemness property can decrease because of enhanced apoptotic cell death and senescence. In addition, aging and aging-related co-morbidities affect the paracrine activity of stem cells and the efficiency of their transplantation. Collectively, this leads to a reduction of the capacity of o...
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Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results from the reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical...
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ژورنال
عنوان ژورنال: Stem Cell Discovery
سال: 2018
ISSN: 2161-6760,2161-6787
DOI: 10.4236/scd.2018.82002